Author Correction: Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering | Scientific Reports

2023-02-19 02:03:44 By : Mr. Zhaobin Teng

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Scientific Reports volume  12, Article number: 9040 (2022 ) Cite this article Ligustilide

Author Correction: Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering | Scientific Reports

The Original Article was published on 12 July 2017

Correction to: Scientific Reports https://doi.org/10.1038/s41598-017-05762-7, published online 12 July 2017

This Article contains errors in Figure 1 and Figure 2.

Osthole reverses defective osteogenic ability of P-PDLSCs. (A) ALP staining and ARS staining after 7 days (ALP staining) and 21 days (ARS staining) in H-PDLSCs and P-PDLSCs with different concentrations of Osthole (0 Mol/L, 10−4 Mol/L, 10−5 Mol/L, 10−6 Mol/L, 10−7 Mol/L and 10−8 Mol/L). (B) Quantification of ARS staining for light absorbance at 562 nm. (C) Gene expression of Runx2, ALP and Osterix in H-PDLSCs, P-PDLSCs and P-PDLSCs with 10−7 Mol/L Osthole as assayed by qRT-PCR. (D) Protein expression of Runx2, ALP and Osterix in H-PDLSCs, P-PDLSCs and P-PDLSCs with 10−7 Mol/L Osthole as assayed by Western blot. *P < 0.05, **P < 0.01, ns: P ≧  0.05, n = 3.

Osthole reverses defective osteogenesis of P-PDLSCs through histone acetylation. (A) ALP staining and ARS staining of H-PDLSCs, P-PDLSCs and P-PDLSCs with 10−7 Mol/L Ostholes in P4 (with stimulation), P6 (without stimulation) and P10 (without stimulation). (B) Quantification of ARS staining for light absorbance at 562 nm. (C) qRT-PCR showed gene expression of fifteen histone acetylases in H-PDLSCs and P-PDLSCs. (D) Protein expression of MOZ, MORF, H3K9ac and H3K14ac in H-PDLSCs and P-PDLSCs as assayed by western blot. (E) qRT-PCR showed gene expression of fifteen histone acetylases in P-PDLSCs and P-PDLSCs with 10−7 Mol/L Osthole measured by qRT-PCR. (F) Protein expression of MOZ, MORF, H3K9ac and H3K14ac in P-PDLSCs with 10−7 Mol/L Osthole treatment on day 0, 3, 5, 7, 10 as assayed by western blot. (G) Level of acetylation of H3K9 and H3K14 in P-PDLSCs with 10−7 Mol/L Osthole treatment on day 0, 3, 5, 7, 10 as assayed by EpiQuik Global Acetyl Histone Quantification Kit. *P < 0.05, **P < 0.01, ***P < 0.001, no mark: P ≧  0.05, n = 3.

In Figure 1A, the ARS staining images in the lower row for H-PDLSC+DMSO and P-PDLSC+Osthole, 10−8 Mol/L are incorrect. Furthermore, in Figure 2A, the APS straining image for H-PDLSC+DMSO in P6 is incorrect. The correct Figure 1 and Figure 2 and accompanying legends appear below.

These authors contributed equally: Jin Sun, Zhiwei Dong and Yang Zhang.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Center for Tissue Engineering, Fourth Military Medical University, Xi’an, 710032, Shaanxi, China

Jin Sun, Xiaoning He, Dongdong Fei, Bei Li & Yan Jin

Xi’an Institute of Tissue Engineering and Regenerative Medicine, Xi’an, 710032, Shaanxi, China

Xiaoning He, Dongdong Fei, Bei Li & Yan Jin

Department of Stomatology, The Affiliated Shenzhen Maternity and Child Healthcare Hospital of the South Medical University, Shenzhen, 518048, Guangdong, China

Department of Oral and Maxillofacial Surgery, General Hospital of Shenyang Military Area Command, Shenyang, 110840, Liaoning, China

Department of Orthopaedics, Xijing Hospital, the Fourth Military Medical University, Xi’an, 710032, Shaanxi, China

Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi’an, 710032, Shaanxi, China

Department of Stomatology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510140, Guangdong, China

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Correspondence to Bei Li or Yan Jin.

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Sun, J., Dong, Z., Zhang, Y. et al. Author Correction: Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering. Sci Rep 12, 9040 (2022). https://doi.org/10.1038/s41598-022-10471-x

DOI: https://doi.org/10.1038/s41598-022-10471-x

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Scientific Reports (Sci Rep) ISSN 2045-2322 (online)

Author Correction: Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering | Scientific Reports

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